PhD Positions (m/f/d) - Structural Biology, Cryo-EM & Biophysics Institution: iMOL Research Training Group (DFG GRK 2566) | Location: Goethe University Frankfurt (Riedberg Campus) | Funding: TV-G-U E13 (65%), 36 Months Join a World-Class Imaging & Structural Biology Network The DFG-funded Research Training Group iMOL connects advanced light and electron microscopy with molecular life sciences. Based at the Buchmann Institute for Molecular Life Sciences (BMLS), iMOL offers a vibrant, interdisciplinary environment. As a key member of the newly formed SCALE Cluster of Excellence (joined in 2026), we foster deep ties with the Max Planck Institutes for Biophysics and Brain Research, the Frankfurt Institute for Advanced Studies (FIAS), and leading international imaging facilities. We are currently seeking two highly motivated PhD candidates for the following specific, fully funded projects supervised by Prof. Dr. Achilleas Frangakis: Project 1: Slit Diaphragm Focus: Structural analysis of the kidney filtration barrier using Cryo-FIB-milling and disease models (FSGS). Full Details: imol.uni-frankfurt.de/slit-diaphragm-phd/ Project 2: Adherens Junctions Focus: 4D structural analysis of cell-cell junctions during Drosophila dorsal closure using Volume EM and MD simulations. Full Details: imol.uni-frankfurt.de/adherens-junctions-phd/ Conduct an independent PhD project at the cutting edge of structural biology and cryo-electron tomography (cryo-ET). Develop and apply advanced correlative workflows (CLEM, super-resolution light microscopy). Perform quantitative image analysis and computational structural biology. Collaborate within an international network of biophysicists, biochemists, and computer scientists. Participate in the structured iMOL qualification programme (workshops, retreats, annual Winter School). Education: Excellent Master's degree (or equivalent) in biochemistry, biophysics, molecular biology, structural biology, or a related discipline. Skills: Experience with cell biological, biochemical, or biophysical experimental methods. Strong interest in advanced microscopy. Language: Fluent in written and spoken English (working language of the institute). Bonus Points: Hands-on experience with cryo-EM, FIB-milling, software like RELION/IMOD/ChimeraX, or programming skills (Python/MATLAB). State-of-the-Art Infrastructure: Access to the Frankfurt Centers for Advanced Light (FCAM) and Electron Microscopy (FCEM), featuring Hesse's first FIB-SEM with nanomanipulator and cutting-edge cryo-microscopes. Financial Support: Fully funded position (E13 TV-G-U, 65%) for 36 months, including a generous budget for consumables, international conferences, and training events. Mentorship: Interdisciplinary co-supervision by leading scientists from Goethe University, Max Planck Institutes, and FIAS. Career Launchpad: Our alumni successfully transition to top international research institutes, global biotech companies, or found high-tech start-ups.