The University Hospital Heidelberg is one of the major healthcare centers in Germany. Our objective is the development of innovative diagnostics and therapies as well as their quick implementation for the patient. With about 14,000 employees in more than 50 specialized clinical departments with almost 2,500 beds, about 80,000 patients in part-time and full-time inpatient treatment as well as 1,000,000 patients in ambulant treatment are medicated each year.
Postdoc - Molecular Biology Research in AML (f/m/d)
wanted of the next possible date for the Department of Hematology, Oncology and Rheumatology in the research group of Prof. Carsten Müller-Tidow .
The Department of Internal Medicine V of Heidelberg University Hospital is a leading center for research in Hematology and Oncology. The location of Heidelberg offers state-of-the-art infrastructure in a highly collaborative environment (NCT, DKFZ and EMBL Heidelberg).
The work of our research group focuses on stem cells and therapy resistance. We aim to understand how epigenetic dysregulation participates in the pathogenesis and chemoresistance of AML. To follow this question a broad number of in-vitro- and in-vivo-models are investigated. The final aim of our studies is to translate the experimental findings into novel treatment strategies for AML patients at diagnosis and relapse.
* Job-ID: V000015018
* Field of application: Klinik für Hämatologie, Onkologie und Rheumatologie
* Location: Heidelberg
* Job Category: Science and teaching
* Working hours: full-time (100 %)
* Limitation: Temporary (24 months, extension is sought)
* Contract: TV-L
Aufgaben
* The postdoctoral fellow will work in a team of enthusiastic biologists and medical scientists with the aim to identify networks in the regulation of human leukemia stem cell activity and to understand the mechanisms of developing and overcoming therapy resistance
* Focus on epitranscriptomic modifications and gene expression with regulation of translation in cancer
* Multi-Omics single cell sequencing approaches to characterize therapy resistance
* Responsible planning and performing of experiments in the framework of the scientific project plan
* Preparation and presentation of project reports and publications
Profil
* PhD in biology, biochemistry or equivalent
* Broad expertise in basic cell-molecular and biochemical techniques (Western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
* Experience and skills in Next-Generation-Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
* Experience in writing scientific reports and papers
* Very good knowledge of and experience with MS office, graphic programs, statistical software, bioinformatics tools and online tools (e. g. Illustrator, Lightroom, GraphPadPrism, R, BLAST)
* Fluent both in written and spoken English language
Wir bieten
* Goal-oriented, individual training and development opportunities
* Working with the latest techniques / technical equipment
* Possibility of mobile working
* Possibility to publish scientifically is offered and supported
* Regular team meetings
* Interdisciplinary cooperation
* Flexible working hours within the framework of flexitime
* Collectively agreed remuneration (TV-L E13), attractive company pension scheme (VBL)
* 30 days vacation
* Sustainable travel: job ticket
* Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
* Wide range of health, prevention and sports offers
More about the research group:
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.
Classification is based on qualifications and personal requirements. The salary (gross) is for a full-time position and does not include the annual bonus or other allowances.
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