Your main responsibilities are:
* Lead the development and optimization of high-resolution LC-MS methods (e.g., Orbitrap, TIMS-TOF) for intact mRNA, oligonucleotide fragments, nucleoside modifications, and related impurities
* Design and execute sample-preparation workflows (enzymatic digestion, chemical derivatization, solid-phase extraction, etc.) to enable sensitive and robust mRNA analysis
* Translate research-grade methods into phase-appropriate, GMP-compliant assays; draft qualification/validation plans, and analytical reports for regulatory submissions (IND/CTA, BLA/MAA)
* Act as analytical SME by providing expert knowledge for internal and external key stakeholders. Support regulatory filings, as well as contributing expertise to questions from health authorities and responses to regulatory submissions
* Provide technical mentorship to junior scientists, research associates, and interns
What you have to offer:
* Ph.D. (or equivalent industrial experience) in Chemistry, Biochemistry, Pharmaceutical Sciences, Molecular Biology, or related discipline
* ≥ 10 years extensive knowledge in method development and data acquisition and analysis with high-resolution mass spectrometers; at least 2 years focused on RNA, oligonucleotide, or nucleic-acid-based therapeutics
* Deep understanding of mRNA structure, chemical modifications, degradation pathways, and formulation impact
* Working knowledge of ICH, USP, Ph. Eur., and FDA/EMA expectations for analytical methods and GMP laboratories
* Demonstrated ability to solve complex problems, successfully manage projects from initiation to completion, and collaborate effectively with cross-functional, multicultural teams to achieve shared goals
* Excellent written and verbal communication skills in English. Proficiency in German is desirable
Join us to shape the next generation of RNA therapeutics through cutting-edge analytical science.
Your Benefits:
It's our priority to support you:
* Your flexibility: flexible hours | vacation account
* Your growth: Digital Learning | Performance & talent development | leadership development | Apprenticeships | LinkedIn Learning
* Your value: Your voice at the table | Culture on an equal footing | Opportunities to shape & impact | Support for your full potential
* Your health and lifestyle: Company bike
* Your mobility: Job ticket | Deutschlandticket
* Your life phases: Employer-funded pension | Childcare
Apply now - We look forward to your application!
Apply to our Martinsried, Germany location by sending us your documents via our online form. For any questions, contact our talent acquisition team on: + 49 (0) 6131-9084-1291 (Monday-Friday from 12 PM to 4 PM CET).
Job ID 9649 (please always specify if you have any questions)
By submitting your application, you acknowledge that a background check will be conducted as part of the recruitment process in accordance with applicable laws and regulations. If you are considered for the position, BioNTech will conduct the background check through our service provider ‘HireRight’. You will be informed accordingly by your BioNTech-Recruiter.