The University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany. The following 65% part-time position is to be filled by September 1st 2025 in the research group Neurohomeostasis, Department of Psychiatry and Psychotherapy of the University Hospital Bonn:PhD Candidate (m/f/d) Due to third party funding, the position is limited to 2 years due the project. Additional 2 years will be covered by a partner institution. Our research focuses on understanding the intricate links between stress, proteostasis, and cellular function, aiming to identify promising therapeutic targets for the treatment of neuropsychiatric disorders. Taking a multidisciplinary and translational approach, we combine cell models, animal experiments, and human studies with protein biochemistry, pharmacology (e.g. autophagy induction, GLP-1 agonists), and advanced multi-omics techniques. The offered project aims to unravel the interplay between metabolic and psychiatric phenotypes by establishing cellular autophagy as a central mechanism linking bi-directional brain-body interactions in stress-related disorders. Analyses of the autophagic pathway along with plasma proteomics and metabolomic polyamine profiling will be performed from human and murine samples. Tasks:Conduct experimental research using advanced molecular and cellular biology techniquesAnalyze and interpret complex biological data to contribute to groundbreaking discoveriesCollaborate with interdisciplinary teams and engage in scientific discussionsPresent findings at conferences and contribute to high-impact publicationsAssist in teaching and mentoring students in the research groupRequirements:Master’s degree in a relevant field, e.g., Biology, Biomedical Sciences, BiochemistryStrong background in cell signaling, proteostasis, and autophagy mechanismsFamiliarity with statistical methods, data analysis, and omics data interpretationHighly motivated, curious, and eager to contribute to scientific advancementsExcellent communication and teamwork skillsFluency in English, both spoken and writtenWe offer:Responsible and versatile: a job with a lot of creative freedom in a collegial teamSecure in the future: fee according to TV-L EG13Flexible for families: flexible working time models, the option of a place in the company day-care center and offers for those returning from parental leaveProvision for later: company pension schemeClever to work: possibility of an interest-free loan to buy an e-bikeTailor-made education: subsidized further education and trainingSystematic start: structured inductionHealthy at work: numerous health promotion offers, free membership in UKBfitEmployer benefits: preferential offers for employees (corporate benefits)We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.How to apply:Do you meet our requirements and are you looking for a varied and challenging job? Do not hesitate and send your detailed application (preferably by e-mail in one file up to 5 MB in size) by June 18th 2025, stating the job advertisement number ST-23056 to: Patricia Schikorra RG Neurohomeostasis Department of Psychiatry and Psychotherapy Universitätsklinikum Bonn Venusberg-Campus 1 53127 Bonn E-Mail: patricia.schikorra@ukbonn.dewww.ukbonn.de