1. Investigate epigenetic mechanisms underlying AML by dissecting how altered chromatin states disrupt differentiation and maintain leukemia in a collaborative team of biologists and medical scientists
2. Focus on chromatin biology and its interplay with transcriptional dysregulation in cancer
3. Work with cell line systems, hiPSC-based disease models, primary patient samples, and PDX models
4. Plan and perform experiments within the framework of the scientific project plan, including epigenetic assays, gene expression analysis, cloning, lentiviral transductions, and genome editing
5. Prepare and present project reports and contribute to publications
6. MD or PhD in biology, biochemistry, molecular biology, or equivalent
7. Strong expertise in molecular biology techniques including Western blotting, immunoprecipitations, epigenetic assays, cloning, cell culture, lentiviral transductions, and gene expression analysis
8. Experience with at least two of the following: flow cytometry, microscopy, NGS techniques and analysis, CRISPR-based epigenetic or genome editing
9. Interest and ideally hands-on experience in bioinformatics analysis of NGS data (ChIP-seq, CUT&Tag, RNA-seq, ATAC-seq)
10. Demonstrated ability in writing scientific reports and papers
11. Proficiency with MS Office, graphic programs (Illustrator, ImageJ), statistical software (GraphPad Prism), and bioinformatics tools (R, BLAST)
12. Fluent in both written and spoken English
13. Goal-oriented, individual training and development opportunities including conferences and workshops
14. Working with the latest techniques / technical equipment in a state-of-the-art research environment
15. Flexible working hours within the framework of flexitime
16. Possibility of habilitation
17. Collectively agreed remuneration according to TV-L E13, attractive company pension scheme (VBL)
18. 30 days vacation
19. Sustainable travel: job ticket
20. Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
21. Wide range of health, prevention and sports offers