Unlocking the Secrets of Membrane Biophysics
The PhD position is focused on investigating the membrane-selective mechanism of Lugdunin, a cyclic heptapeptide produced by Staphylococcus lugdunensis.
This project aims to unravel the molecular interactions and structural determinants underlying the antimicrobial activity and membrane selectivity of Lugdunin. An interdisciplinary approach combining experimental and computational methods will be employed to investigate the specificity of Lugdunin for gram-positive bacteria and its unique membrane lipid composition.
Key Objectives:
* To elucidate the molecular mechanisms behind Lugdunin's antimicrobial activity against multi-resistant gram-positive bacteria.
* To determine the structural features of Lugdunin responsible for its membrane selectivity.
* To develop novel antimicrobial peptides and innovative approaches to combat infections caused by multi-resistant bacteria.
This study has the potential to pave the way for groundbreaking research in the field of biophysics and medicine. We are seeking an enthusiastic candidate with a strong passion for interdisciplinary projects and collaboration with experimental physics, chemistry, medical, and immunology groups.
Required Skills and Qualifications:
* Master's degree in bio-/physics, theoretical/computational chemistry, life sciences, or a related field.
* Strong proficiency in English and effective communication skills.
* Ability to thrive in a collaborative and dynamic research environment.
About This Opportunity:
Located at the Friedrich-Alexander University of Erlangen-Nürnberg, a vibrant academic center with a focus on immunobiology and home to the National High-Performance Computing Center NHR@FAU.