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Doctoral candidate (f/m/d)
Operational area: Clinic for Gastroenterology, Metabolic Diseases and Internal Intensive Care Medicine (Med. Clinic III) -AG Professor Dr. Pavel Strnad/Dr. hum. biol. Nurdan Güldiken-
Working hours: Part-time 65% (currently 25,3 hours/week)
Duration/Term of employment: Initially limited to 3 years in accordance with the WissZeitVG. The successful candidate is expected to pursue a doctoral degree.
Start date: As soon as possible
Remuneration/Rates: EG 13 (TV-L)
Are you interested in uncovering the molecular mechanisms underlying epithelial integrity and organ injury in the esophagus and lung? Join our research team with strong expertise in cell and tissue biology, organ pathophysiology, and translational biomedical research.
Project: PhD Opportunities: Desmoplakin-Related Epithelial and Pulmonary Biology
* Investigate the role of desmoplakin (DSP) in maintaining epithelial barrier function in the esophagus and lung tissue
* Analyse how alterations in DSP expression, desmosomal structures, and cell–cell adhesion mechanisms contribute to diseases such as eosinophilic esophagitis, lung injury, or fibrosis
* Study human tissue samples, cell culture models (epithelial cell lines and possibly 3D cultures)
* Perform omics-based approaches (RNA-seq, proteomics), and functional assays (e.g., transepithelial resistance, cell migration, and adhesion studies).
* The overall goal is to increase our understanding of DSP biology in the esophagus and lung and thereby to pave the way for new diagnostic or therapeutic strategies
Tasks:
* Independent development and advancement of own research project
* Active contribution to ongoing research initiatives
* Support in the education and supervision of students
* Preparation and publication of scientific manuscripts
Profile:
* Master's degree in Life Sciences or related field
* Background in biology, molecular biology, immunology, or related disciplines
* Experience in basic and translational research
* Experience with model organisms and bioinformatics tools is welcome
* Ability to independently drive research projects
* Proficiency in English, with strong communication and leadership skills (Level C1)
Why choose us?
We offer…
* 30 days of vacation
* A bonus of 3,000 euros for employees who help recruit employees in the care sector
* An attractive company pension scheme from VBL
* Education opportunities, including updating and upgrading
* Access to public transport
* In-house kindergarten (places subject to availability)
* Staff residences (places subject to availability and by arrangement)
* An onboarding app for new employees
* Extended opening hours in the staff restaurant