Informationen zum Job Weitere Informationen The successful candidate will be employed under a regular employment contract. The position is to be filled at the earliest possible date and offered for a fixed term for 3 years. The fixed-term employment is possible as it constitutes one of the fixed-term options of the Wissenschaftszeitvertragsgesetz (German Act on Fixed-term Scientific Contracts). This is a part-time contract position. The standard weekly hours will be 26,55 hours. The successful candidate has the opportunity to pursue a doctoral degree in this position. The salary is based on the German public service salary scale (TV-L). The position corresponds to a pay grade of EG 13 TV-L. Unser Profil We study molecular-recognition events in biology and chemistry by magnetic-resonance spectroscopy. This is achieved by developing and applying a set of dedicated solid-state Nuclear Magnetic Resonance (NMR) experiments enabling the detection and quantification of noncovalent interactions that are guiding such processes at the molecular level. In that vein, the group currently focuses on four selected molecular recognition processes, namely cellular organization by phase separation events, ATP-hydrolysis in ATPases, solid-state molecular recognition processes in organic mechanochemistry and recognition of substrate molecules on immobilized catalyst surfaces. The lab located at the Institute of Technical and Macromolecular Chemistry at RWTH Aachen University is equipped with NMR spectrometers up to 700 MHz enabling magic-angle spinning (MAS) experiments up to 111 kHz. Ihr Profil Successful candidates should have a science education (university degree Master's or equivalent) in chemistry, physics or biology and a strong interest in spectroscopic techniques. The candidate should be interested in biochemical laboratory work. Your complete application should contain a curriculum vitae (CV) and the names of two professional references whom we may contact, which should also be sent by e-mail to Prof. Dr. Wiegand. Ihre Aufgaben Protein-nucleotide interactions play a central role in biology and control a variety of processes, such as ATP hydrolysis and DNA replication, both relying on very specific molecular interactions for adequate functionality. This project aims at expanding and applying our solid-state NMR toolbox to probe protein-nucleotide interactions using the example of the ATPase SmsC belonging to the Sms-system responsible for the formation of Fe-S clusters. From a methodological perspective, we aim among others at introducing 19F-detected solid-state NMR at fast MAS frequencies (>100 kHz) into our toolbox allowing us to derive distance restraints between 19F-labelled nucleotides and the protein. Such studies will be complemented by proton-detected experiments enabling the positioning of the nucleotide phosphate backbone in the nucleotide-binding domain, as well as by 31P-31P distance measurements to probe the phosphate geometry. We aim at deriving a detailed understanding of the mechanism of ATP-hydrolysis in the ATPase SmsC, e.g. by performing real-time solid-state NMR studies employing suitable ATP-mimics. For some selected publications see Wu, Zehnder, Schröder, et al. J. Am. Chem. Soc. 2024, 146, 9583–9596; Malär et al. Nat. Commun. 2021, 12, 5293; Wiegand, Schledorn, et al. ChemBioChem. 2020, 21, 324-330. Über uns RWTH is a certified family-friendly University. We support our employees in maintaining a good work-life balance with a wide range of health, advising, and prevention services, for example university sports. Employees who are covered by collective bargaining agreements and civil servants have access to an extensive range of further training courses and the opportunity to purchase a job ticket. RWTH is an equal opportunities employer. We therefore welcome and encourage applications from all suitably qualified candidates, particularly from groups that are underrepresented at the University. All qualified applicants will receive consideration for employment and will not be discriminated against on the basis of national or ethnic origin, sex, sexual orientation, gender identity, religion, disability or age. RWTH is strongly committed to encouraging women in their careers. Female applicants are given preference if they are equally suitable, competent, and professionally qualified, unless a fellow candidate is favored for a specific reason. As RWTH is committed to equality of opportunity, we ask you not to include a photo in your application. You can find information on the personal data we collect from applicants in accordance with Articles 13 and 14 of the European Union's General Data Protection Regulation (GDPR) at http://www.rwth-aachen.de/dsgvo-information-bewerbung. Besoldung / Entgelt EG 13 TV-L