Project Description:
The project aims to manipulate the immune landscape of tumors by delivering targeted mRNA combinations to specific cell populations within the tumor microenvironment (TME), with the goal of enhancing immune activation and overcoming immunosuppressive barriers.
Your tasks:
* Design and execute combinatorial mRNA delivery strategies targeting immune, stromal and cancer components of the TME
* Employ RNA-lipid nanoparticle systems for spatially controlled gene expression
* Conduct deep phenotyping of cells in tissues using high-parameter flow cytometry and multiplex 3D imaging
* Use advanced in vitro and ex vivo tumor models to validate therapeutic efficacy
* Collaborate closely with experimental and clinical colleagues from Mainz and Heidelberg
* Present findings in internal meetings and scientific conferences, and contribute to manuscript preparation
Your Profile:
* Master’s degree (or equivalent) in immunology, molecular biology, biotechnology, bioengineering, or a related field
* Strong interest in cancer immunotherapy, RNA therapeutics, and tumor immunology
* Hands-on experience in molecular biology techniques, cell culture and flow cytometry
* Experience in RNA handling and nanoparticle formulation is a plus
* Prior knowledge of immunological methods (ELISA, ELISpot, IHC/IF staining) and microscopy is desirable
* Willingness to work with blood and tissue samples, and animal models
* Motivation to work in a dynamic, interdisciplinary, and translational research environment
* Good communication skills in English (spoken and written)
* Strong analytical mindset, organizational skills, and ability to work both independently and as part of a team
We Offer
Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
Access to international research networks
Doctoral salary with the usual social benefits
30 days of vacation per year
Flexible working hours
Possibility of part-time work
Family-friendly working environment
Sustainable travel to work: subsidized Germany job ticket
Unleash your full potential: targeted training and mentoring through the DKFZ International PhD Program and DKFZ Career Service
Our Corporate Health Management Program offers a holistic approach to your well-being