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Master thesis for multiplex digital pcr using high-density microwell arrays (m/f/x)

Freiburg im Breisgau
Abschlussarbeit
Hahn-Schickard-Gesellschaft für angewandte Forschung e.V.
Master
Inserat online seit: Veröffentlicht vor 2 Std.
Beschreibung

Vision to Products

Welcome to Hahn-Schickard: The research center for innovative microsystems technology. With a team of over 300 employees, we transform ideas into cross-industry solutions - from conception to production at four locations in Baden-Württemberg. At our Freiburg site, the emphasis is on developing analytical solutions in microsystems technology, particularly for point-of-care diagnostics.

For the area of Microfluidic Platforms in Freiburg, we offer from 01.04.2026 or later a


Master Thesis for Multiplex digital PCR using High-Density Microwell Arrays (m/f/x)


Aim of the thesis

* Multiplexing in digital PCR is often limited by "partition-specific competition" in commercial devices (≈25,000 partitions), where co-encapsulated targets compete for reagents.
* The goal of the thesis is to demonstrate how a LabDisk, with its high-density array of 250,000 microwells, eliminates this competition to ensure robust quantification of liquid biopsy targets like KRAS.


Your Tasks

* Assay Development: Implement a multiplex Mediator Probe dPCR assay on the LabDisk.
* Comparison: Validate LabDisk performance against commercial dPCR systems.
* Data Analysis: Analyze high-density multiplex data.


Your profile

* Studies: Biochemistry, Biotechnology, Molecular Biology, Medical Engineering, or a related STEM discipline.
* Skills: Lab experience (pipetting/ PCR) and interest in bioanalytics.
* Work Style: Independent and structured.
* Language: Good English or German


Our offer to you

* Flexible working hours
* Insights into current digital PCR development for molecular diagnostics
* Close supervision and the opportunity to contribute your own ideas
* A young and dynamic team
* An attractive workplace in a modern, excellently equipped research institute that is close to industry
* Participation in first-class health programmes such as Hansefit
* Subsidy for meals
* Subsidies for public transport


Your Application

Mr. Dr. Peter Jülg will be pleased to answer any question you may have.

Peter.Juelg@hahn-schickard.de / Tel.: +49 761 203-95421

If you are interested, please send us your complete application documents (motivation letter/resume+CV/certificates/transcript of records), stating the reference number 26/3240/02 in a complete PDF document and naming the job portal here online via the application form.

The decision is made directly by the division.

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