Wissenschaft und Forschung
Research Associate (m/f/d) – Molecular Immunology
Veröffentlicht:
Full- or part-time | temporary (33 months) contract | Institute for Molecular Immunology
2 PhD positions (f/m/d) in the field of immune regulation in autoimmune liver diseases (ALD) Project summary: In two DFG-funded projects within the DFG-funded SFB Transregio initiative TRR179, we investigate the mechanisms determining the control of persistent infection with the Hepatitis B Virus. Persistent HBV infection in more than 250 million individuals worldwide causes chronic hepatitis and ensuing complications like liver cirrhosis and liver cancer. We aim to understand the molecular mechanisms by which virus-specific CD8 T cells are rendered dysfunctional through a recently published liver immune rheostat mechanism (Bosch et al. Nature In a second project, we aim to overcome the defect of conventional virus-specific CD8 T cells to eliminate virus-infected hepatocytes by harnessing a particular effector CD8 T cell function to execute auto-aggressive killing (Dudek et al. Nature The results of the projects are intended to be used as a starting point for developing novel immune therapies to combat chronic hepatitis B.
Your responsibilities:
Investigation of tissue-derived molecular mechanisms regulating CD8 T cell effector functions in organs such as the liver
Handling of cutting-edge techniques like multi-parametric flow cytometry, high-dimensional cytotoxicity assays, (phospho-)proteomics, MALDI-imaging, and preclinical mouse models of viral infections of the liver
Your profile:
University degree in natural or life sciences
Preferably, hands-on experience with human or murine primary cells, cell culture and flow cytometry
Preferably, expertise in immunology and experience in working with mice
Team-player qualifications and good communication skills
We offer you:
EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers
Free use of the library through a branch of the Munich City Library located in the building
Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram
Self-realization through a varied and technically demanding job with interdisciplinary cooperation
We look forward to your application
Contact: Prof. Dr. Percy Knolle | 089 / 4140 –6920 | Institute for Molecular Immunology
Please submit your complete application documents by e-mail including
reference number 25_08_027
your preferred starting date.
Institute for Molecular Immunology
TUM Klinikum
Rechts der Isar
Ismaninger Straße 22
81675 München
E-Mail:
If the candidates' suitability for the position in question is equal, severely disabled applicants shall be given preference. Interview-related costs can, unfortunately, not be reimbursed.