Research Scientist Opportunity
The primary focus of this role will be to investigate the mechanisms by which fibroblasts from healthy colon tissue transition into distinct cancer-associated fibroblast subtypes, and how these subtypes influence epithelial plasticity and immune responses in colorectal cancer.
This research will integrate spatial transcriptomics, advanced co-culture organoid assays, and in vivo models to decode the complex interactions between cancer cells, stromal cells, and the tumor microenvironment.
The person in this position will apply cutting-edge bioinformatics approaches to human-relevant models and unique patient-derived tissue cohorts from colorectal cancer, with a focus on dissecting the functional heterogeneity of epithelial cells, cancer-associated fibroblasts, and immune cells.
Key objectives include comprehensively profiling the phenotypic and functional diversity of these cell types, as well as their lineage plasticity and evolutionary dynamics, in order to understand the underlying drivers of cancer progression and therapy resistance.