We employ experimental autoimmune encephalomyelitis (EAE) as an animal model of multiple sclerosis. Specifically, we used two-photon microscopy to visualize the motility of autoantigen specific T cells throughout the process of T cell infiltration into the CNS in living animals. Recently, we used CRISPR gene editing to identify critical regulators of autoantigen specific T cell infiltration into the CNS. We are now seeking a PhD candidate to further investigate the molecular mechanism of T cell infiltration and activation in the CNS using these cutting-edge technologies, including CRISPR gene editing and intravital imaging, together with advanced methods of molecular biology. Candidates should have a Master’s degree in Biology, Immunology or a related subject. We are looking for candidates who are highly motivated, good team players, yet capable of working independently. Candidates should be fluent in English. We prefer candidates with basic experience in fluorescence/confocal microscopy, experimental animal handling, flow cytometry, and cell culture. The position is funded by DFG. The salary will be according to the German model for the public sector (TV-L E13, 65%). The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference.