Institute of Neuropathology - University Medical Center Freiburg (Germany) Lab: Neuroimmune Systems Biology - Dr. Emile Wogram Start: As soon as possible The Neuroimmune Systems Biology Lab at the Institute of Neuropathology (University Medical Center Freiburg) is seeking a highly motivated PhD student to investigate how organelle networks regulate brain homeostasis and drive neurodegeneration in Alzheimer’s disease. Neurodegenerative diseases such as Alzheimer’s disease (AD) arise from complex interactions between brain cell types. Increasing evidence suggests that intracellular organelle networks - including lysosomes and mitochondria - coordinate metabolic and immune pathways that maintain brain homeostasis, yet how these systems fail in neurodegeneration remains poorly understood. This PhD project, as part of the AD-OrganelleScan initiative, aims to uncover organelle-level mechanisms of Alzheimer’s disease using organelle-resolved multiomics and systems biology approaches as: Isolation of organelles from brain cells Multiomic profiling and analysis to identify disease mechanisms Experimental validation The goal is to identify subcellular mechanisms driving neurodegeneration and potential therapeutic targets. Master’s degree in Neuroscience, Molecular Medicine, Biochemistry, or a related field Intellectual curiosity and motivation to tackle complex, important biological questions Good written and spoken English The project is hosted at the Institute of Neuropathology, IMITATE, Freiburg, Germany, a leading center for translational neuroscience research in Germany. The candidate will benefit from: Access to state-of-the-art multiomics, imaging, and stem cell platforms A highly interdisciplinary environment linking neuroscience, immunology, and systems biology Close supervision and structured PhD mentoring Salary is provided according to TV-L E13 (65%).