Job Description
* You will generate CAR T-cells from primary human material using isolation, activation, transduction, and expansion techniques.
* You will perform co-culture assays to validate CAR T-cell performance, including cytotoxicity, activation, and cytokine production measurements.
* You will develop co-culture assays to assess the impact of impact of biophysical parameters (e.g. ECM stiffness, hypoxia, and lactate) on CAR T-cell performance.
* You will perform transcriptional profiling on CAR T-cells to elucidate molecular mechanisms affected by biophysical parameters, such as through RNA-seq analysis.
* You will apply CRISPR/Cas9 genome editing to modify T-cells, targeting genes for enhanced resistance to tumor microenvironment stressors.
* This position offers you a unique opportunity to obtain your Master’s degree while staying abreast of the latest developments in genetic engineering and cellular therapies.
* Your workplace will be in Bergisch Gladbach.
Qualifications
* You are an enrolled student and have a Bsc. degree in genetics, immunology or a related field.
* You are curious and eager to learn.
* Teamwork and open communication are part of your key values
* You are well organised, flexible, and conscientiously document your laboratory results.
* You should be familiar with cellular biology techniques e.g. flow cytometry. Experiences with CAR T cells is a plus.
* You should have basic computational skills, such as familiarity with bioinformatics.
* You are fluent in English.
Additional Information
What we offer
* A modern workplace and exciting opportunities in the development of technologies with a secure future.
* Diversity: International teams and cross-border intercultural communication
* Room for creativity: It’s the most clever solution that we always strive for
* Health & Sport: We offer a wide range of corporate sports activities and health provision
* Miltenyi University: A clever mind never stops learning, take advantage of our inhouse Training Academy
Diversity is the bedrock of our creativity.
Our mission: To innovate treatments and technologies and tackle the world’s most serious health challenges. And that’s why we connect the dots –across various disciplines, linking different perspectives, skills, and abilities.
You and your talent are welcome here in our inclusive and collaborative environment. So come as you are. Regardless of gender, sexual identity, age, ethnicity, religion or disability.
Become part of our team and focus on pushing the borders of medicine.
We are looking forward to your application
You have the skills and qualifications required for this position, please use the link to send us your documents (cover letter, resume, references and certificates).
Please give us an idea of when you could start and what your salary expectations are.