1. The postdoctoral fellow will work in a team of enthusiastic biologists and medical scientists with the aim to identify networks in the regulation of human leukemia stem cell activity and to understand the mechanisms of developing and overcoming therapy. resistance. MLLr acute leukemia is the target in this project
2. Focus on epitranscriptomic modifications and gene expression with regulation of translation in cancer
3. Multi-Omics single cell sequencing approaches to characterize therapy resistance
4. Responsible planning and performing of experiments in the framework of the scientific project plan
5. Preparation and presentation of project reports and publications
6. PhD in biology, biochemistry or equivalent
7. Proven experience in research of MLLr acute leukemia
8. Broad expertise in basic cell-molecular and biochemical techniques (Western blotting, immunoprecipitations, ChIP, gene expression analysis, cloning, cell culture, lentiviral transductions, flow cytometry, microscopy etc.)
9. Experience and skills in Next-Generation-Sequencing, CRISPR/CAS9, shRNA-mediated knock down and genome editing techniques
10. Experience in writing scientific reports and papers
11. Very good knowledge of and experience with MS office, graphic programs, statistical software, bioinformatics tools and online tools ( Illustrator, Lightroom, GraphPadPrism, R, BLAST)
12. Fluent both in written and spoken English language
13. Goal-oriented, individual training and development opportunities
14. Working with the latest techniques / technical equipment
15. Possibility of mobile working
16. Flexible working hours within the framework of flexitime
17. Possibility of doctorate
18. Possibility of habilitation
19. Possibility to publish scientifically is offered and supported
20. Regular team meetings
21. Interdisciplinary cooperation
22. Collectively agreed remuneration TV-L E13, attractive company pension scheme (VBL)
23. 30 days vacation
24. Sustainable travel: job ticket
25. Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
26. Wide range of health, prevention and sports offers