About the job
Join the Metabolism Research Group at Sanofi Frankfurt
The Metabolism Research group at Sanofi's BioCampus Frankfurt is a vital component of our global Lab Science / TMU organization. We are at the forefront of biotransformation research, specializing in the elucidation of metabolites for both new chemical and biological entities.
Our team's core objectives span all global Sanofi programs and include :
* Identifying metabolic liabilities: We pinpoint potential issues early in research and drug development processes.
* Optimizing drug candidates: Our work directly contributes to enhancing the efficacy and safety of potential treatments.
* Detecting reactive metabolites: We strive to mitigate risks of adverse effects, ensuring safer drug development.
* Discovering pharmacologically active metabolites: Our investigations may uncover new therapeutic candidates.
As part of Sanofi's innovative Immunoscience approach, we collaborate closely with multidisciplinary teams, including experts in research, development, pharmacology, and toxicology.
Your Main Responsibilities :
* Conduct independently biotransformation studies of novel biotherapeutics (nanobodies, antibodies) within our metabolism laboratory team.
* Develop and implement tailored LC-MS strategies and workflows to analyze in vitro and in vivo studies and identify biotherapeutic degradation products.
* Drive innovation by implementing cutting-edge analytical technologies and proteomic/metabolite identification software.
* Develop automated workflows to enhance data evaluation efficiency and establish models predicting biotherapeutics instabilities.
* Present and discuss your results with global metabolism experts, project teams, and Lab Sciences colleagues.
About you
Required Qualifications :
* Extensive hands-on experience with :
o Ultra-high resolution MS instrumentation
o Multiple fragmentation techniques (CID / ETD)
o Manual MS spectra interpretation
o Proven expertise in protein characterization methodologies (Top-Down, Middle-Down, Bottom-up approaches) and extraction technologies (immunocapture approach)
o Advanced MS data processing and analysis capabilities, preferably for proteomics analyses
o Experience in protein chromatography (µPLC / micro-LC / nano-LC)
Professional Skills :
* Excellent communication and presentation skills
* Track record of contributing to scientific publications
* Strong collaborative mindset for cross-functional team environments
* Experience in biotransformation of biotherapeutics (preferred)
Education :
* PhD degree in biochemistry, analytical chemistry, food chemistry, or pharmacy
Language Requirements : German / English : fluent in speaking, reading, writing
Why choose us?
* Bring the miracles of science to life alongside a supportive, future-focused team.
* Discover endless opportunities to grow your talent and drive your career, whether through promotion or lateral moves, at home or internationally.
* Benefit from a well-thought-out benefits package that rewards your contribution and commitment.
* Start your career at an attractive location in the center / in the capital of Germany and experience our modern working environment with hybrid, flexible working time models.
Pursue Progress. Discover Extraordinary.
Progress doesn't happen without people — people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas, and exploring all the opportunities we have to offer. Let's pursue progress. And let's discover extraordinary together.
At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity.
Watch our ALL IN video and check out our Diversity, Equity, and Inclusion actions at sanofi.com!
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Diversity and inclusion are core values at Sanofi and are reflected in our way of working. We respect the diversity of our workforce in terms of their backgrounds, experiences, and lifestyles. We recognize the enrichment this diversity offers and promote inclusion and an environment where these differences can thrive, strengthening the lives of our employees, patients, and customers.
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