From Nov 1st at the Neuropathology Department at Heidelberg University Hospital.
The Division of Molecular Neuropathology is seeking an ambitious bioinformatician for the development of workflows for intra-operative nanopore sequencing in the diagnosis of brain tumors.
As one of the largest neuro-oncology diagnostic centers in Europe, we are deeply embedded in the clinical care of thousands of patients each year. We are now pursuing a transformative vision: bringing real-time sequencing directly into the operating theater to inform surgical decision-making and dramatically accelerate diagnostic turnaround.
Building on our proof-of-concept study RAPID-CNS2 (Patel et al., Nat Med 2025), this position will focus on translating real-time sequencing into a clinically robust diagnostic tool. The work will encompass the advancement of intra-operative sequencing workflows with diagnostic-grade read depth, the implementation and refinement of so-called "double adaptive sequencing" strategies, and the establishment of reliable approaches for the rapid detection of clinically relevant gene fusions. A further challenge will be the extension of this methodology beyond fresh tissue, with particular emphasis on adapting protocols to formalin-fixed paraffin-embedded (FFPE) samples, thereby broadening its applicability to routine diagnostics.
As a core member of our interdisciplinary team of neurosurgeons, molecular pathologists, and computational scientists, you will play a central role in shaping the next generation of molecular diagnostics in neuro-oncology. Your work will be pivotal in moving nanopore sequencing from proof-of-concept into clinical routine, redefining standards for precision diagnostics and supporting intra-operative decision-making.
This position offers a unique opportunity to work at the cutting edge of translational bioinformatics, developing novel and time-critical sequencing workflows that will directly impact patient care and set new benchmarks for neuro-oncology.
Job-ID:
V
Field of application:
Neuropathologie
Location:
Heidelberg
Job Category:
Science and teaching
Working hours:
full-time (100%)
Published:
Limitation:
Temporary (3 years)
Contract:
TV-L
Your tasks
* Manage, optimize, and extend our nanopore sequencing workflows for intra-operative diagnostic use.
* Develop novel computational approaches at the forefront of long-read sequencing technologies.
* Ensure the seamless integration of real-time sequencing analyses into patient care and intra-operative decision-making.
* Prepare scientific publications and present our advances at international conferences.
Your profile
* A degree in computational biology, bioinformatics, or a related field. Applications on various entry levels are welcome. This can also be a great postdoctoral opportunity.
* Experience with genomics analysis pipelines, ideally including familiarity with long-read sequencing data from Oxford Nanopore Technologies (ONT).
* Strong analytical and problem-solving skills, with a structured and results-oriented mindset.
* A collaborative spirit and the ability to thrive in an interdisciplinary environment.
* Awareness of the clinical relevance of the work.
What we offer
* Collectively agreed remuneration TV-L E 13, attractive company pension scheme (VBL)
* Goal-oriented, individual training and development opportunities (e.g. use of AI applications in ONT analysis)
* Working with the latest techniques / technical equipment for long-read sequencing
* Flexible working hours within the framework of flexitime
* Possibility of doctorate an habilitation
* Possibility to publish scientifically is offered and supported
* Regular team meetings and Interdisciplinary cooperation with leading experts in the fields of neuropathology, molecular biology and computer science
* Possibility to take over project responsibility for the intra-operative Molecular Neuropathology diagnostic pipeline development
* 30 days vacation
* Sustainable travel: job ticket
* Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
* Wide range of health, prevention and sports offers
Contact & Application
For further information please contact Dr. Isabell Bludau via
Interested?
Applications will be accepted until direct online.
Neuropathologie
Prof. Dr. Dr. med. Felix Sahm – stv. Ärztlicher Direktor
Im Neuenheimer Feld 224
69120 Heidelberg
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.
Classification is based on qualifications and personal requirements. The salary (gross) is for a full-time position and does not include the annual bonus or other allowances.