Tasks:
The project aims to establish vascularized 3D colorectal tumor spheroids within mesoscopic, MRI-compatible bioreactors and to validate a newly developed, DWI-based biophysical modeling approach of the tumor microenvironment.
1. Establishment and cultivation of vascularized, heterotypic murine tumor spheroids in perfusable, MRI-compatible bioreactors; protocol development and quality control
2. Preparation and conducting of MRI measurements in cooperation with "Faber research group" Münster, including exchange between both groups
3. In-vitro therapy screening and histological validation using bioreactor systems
4. In-vivo therapy screening (mouse models)
5. Data analysis and fitting of the applied biophysical model
6. Documentation, preparation of publications, and presentation of results at conferences
Profile:
7. Master of Science in Biotechnology, biomedicine, chemistry, etc.
8. Solid cell culture expertise ideally in 3D systems (spheroids/organoids) or co-culture systems as well as primary endothelial and stromal cultures
9. Motivation to learn MRI workflows (DWI/TDD) and to work with cooperation partners on biophysical modeling and implementation
10. Desirable: Experience in biocompatible hydrogels (collagen/fibrin/gelatin) Experience in bioprinting would be advantageous Histological processing of samples (sectioning, IHC/IF staining, in microscopy) Basic knowledge of MRI (methods, sequence protocols, data analysis)
11. Structured, independent and team-oriented approach to working in an interdisciplinary environment
12. Strong English skills, both spoken and written (minimum C1, preferably C2); Good German language skills are an advantageous
13. Strong team spirit and willingness to work collaboratively between the institutes in Aachen and Münster
14. Accuracy and diligence in documentation (good laboratory practice), reliable project and sample management
15. Strong problem-solving approach and hands-on mentality when establishing new setups and protocols
16. •Good presentation skills are advantageous
Why choose us?
We offer…
17. 30 days of vacation
18. A bonus of 3,000 euros for employees who help recruit employees in the care sector
19. An attractive company pension scheme from VBL
20. Education opportunities, including updating and upgrading
21. Access to public transport
22. In-house kindergarten (places subject to availability)
23. Staff residences (places subject to availability and by arrangement)
24. An onboarding app for new employees
25. Extended opening hours in the staff restaurant