PhD-Student (gn*) Life Sciences, Inflammation ResearchFixed-term of 3 years | Part-time with 65% (25 hours/week) | Salary according to TV-L E13 | The Institute for Experimental Pathology | Job ID: 10417We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.To meet our high standards every day, we are looking forward to your scientific expertise in the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster - ideally with you on board!PROJECT TITLE: Investigating the Interaction between Infection and Vascular Inflammation THE INSTITUTE AND PROJECT: The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation with specific focus on atherosclerosis and its complications such as myocardial infarction and neointimal hyperplasia (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group's mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group's work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on cardiovascular inflammation and funded by the Deutsche Forschungsgemeinschaft.Your TasksDesign and conduct experiments utilizing state-of-the-art approaches such as: Animal models of infection and atherosclerosisFlow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometryImmunohistological staining and imaging of tissue sections using multiplexed immunohistochemistryBiochemical assays for cytokines and other inflammatory mediatorsCollaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of atherosclerosis pathophysiologyAnalyze data, interpret results, and present conclusions through high-quality publications, presentations, and reportsContribute to manuscript preparationParticipate actively in departmental seminars, workshops, and conferencesWhat we expect: MSc degree in Biological SciencesStrong background in immunology and/or vascular biologyExpertise in one or more of the following areas: Flow cytometry-based phenotyping and sortingImmunofluorescence microscopy and histopathological evaluationStatistical programming languages like R or PythonGood communication skills in English; proficiency in German desirable but not required Willingness to work independently while contributing effectively to collaborative projectsWillingness to participate in ongoing training programs to enhance expertise and stay up -to -date with latest methodologiesWhat we offer: Benefits package including health insurance, pension plan, and family support servicesAccess to world-class infrastructure, equipment, and resourcesOpportunities for professional growth, networking, and international collaborationSupportive environment fostering creativity, innovation, and interdisciplinary exchangeFor inquiries, please contact: Oliver Soehnlein, T 0251 83-53001Apply now via our career portal until 02.06.2025 including:Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)Curriculum Vitae with publication list and academic recordContact details for two referees familiar with your scientific achievementsBENEFITSExciting ProjectsProfessional Development and TrainingInterdisciplinary CollaborationPart of Research InnovationAdditional BenefitsExciting ProjectsProfessional Development and TrainingInterdisciplinary CollaborationPart of Research InnovationAdditional Benefits(*gn=gender neutral)The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.Universitätsklinikum Münster Albert-Schweitzer-Campus 1, Gebäude D5 48149 Münster www.ukm.de