About the job Join the engine of Sanofi's mission - where deep immunoscience meets bold, AI-powered research. In R&D, you'll drive breakthroughs that could turn the impossible into possible for millions. Ready to shape the future of medicine through cutting-edge pharmacometrics? Join Sanofi's Pharmacometrics Research Group Germany and accelerate drug discovery from hit identification to translation for first-in-human studies! About Sanofi: We're an R&D-driven, AI-powered biopharma company committed to improving people's lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people's lives. Key Responsibilities Modeling & Simulation Excellence Support early and late research project teams with state-of-the-art quantitative approaches enabling data-based decision making. Among others your activities will include: Conduct comprehensive early feasibility analyses (EFA) to assess compound viability and guide project progression decisions Perform non-compartmental analysis (NCA) and empirical pharmacokinetic/pharmacodynamic (PK/PD) modeling to characterize drug exposure-response relationships and impact in vivo study designs Develop and validate population pharmacokinetic (popPK) models using advanced mixed-effects modeling and physiologically-based pharmacokinetic (PBPK) modeling approaches Apply translational modeling approaches to bridge preclinical and clinical PK/PD data, establish in vitro in vivo correlations (IVIVC), conduct and evaluate allometric scaling methodologies for cross-species extrapolation to predict human pharmacokinetics Advanced Analytics & Innovation Apply and integrate innovative machine learning methods and descriptive statistics to extract insights from complex datasets Develop predictive and descriptive models using R, Python, and Julia programming languages Support automated workflows and visualization tools to enhance modeling efficiency Project Leadership & Collaboration Serve as the pharmacometrics representative in cross-functional project teams Provide strategic modeling guidance from target identification through clinical candidate selection Support first-in-human (FIH) dose selection and clinical study design optimization Collaborate with in vitro, in vivo, toxicology, and biostatistics groups Contribute to regulatory submissions and interact with health authorities when required Scientific Communication & Development Present findings at internal project meetings and external scientific conferences Publish research in peer-reviewed journals to advance the field of pharmacometrics Prepare comprehensive modeling reports and regulatory documents Opportunities to mentor junior scientists and contribute to team capability building Required Qualifications & Experience Education & Experience PhD in pharmacometrics, pharmaceutical sciences, applied mathematics, systems biology, bioengineering, bioinformatics, or related quantitative field Experience in pharmaceutical industry, regulatory agencies, or academia is desirable Track record of applying PK/PD modeling & simulation in drug development context Technical Expertise Proficiency in pharmacometrics software tools and programing languages ( R, python, Julia, Pumas, OSP-suite (PK-Sim/MoBi), SimCyp, NONMEM, Monolix) Solid understanding of ADME principles across multiple modalities (small molecules, biologics (antibodies, nanobodies), RNA therapeutics, PROTACs) Expertise in machine learning applications in drug development beneficial Experience with real-world preclinical and clinical PK/PD data analysis Knowledge of regulatory guidelines and industry best practices Core Competencies Strategic thinking with ability to identify opportunities for model-informed drug development Problem-solving skills to address complex pharmacological questions Communication excellence to convey technical concepts to diverse audiences Collaborative mindset for working in matrix organizations and international teams Scientific rigor in model development, validation, and documentation Language Requirements Excellent written and verbal communication skills in English German language skills are advantageous but not required Why choose us? Be part of a pioneering biopharma company that engages patients early in drug development and uses their insights to design studies that reflect real-world needs. Work at the forefront of drug discovery, harnessing cutting-edge AI, data, and digital platforms to push the boundaries of science. Help improve the lives of millions of people globally by making drug development quicker and more effective. Enjoy opportunities to collaborate beyond your area of expertise, working with diverse teams across science, clinical, and digital fields to spark new ideas and drive breakthroughs. Benefit from a well-thought-out benefits package that rewards your contribution and commitment. LI-Onsite Pharmacometrics DrugDevelopment PKPD Modeling Sanofi SanofiCareers DiscoverExtraordinary SanofiStories WeNeverSettle TeamSanofi IgnitingPotential Diversity und Inklusion sind in den Grundwerten von Sanofi verankert und spiegeln sich in unserer Arbeitsweise wider. Wir respektieren die Vielfalt unserer Belegschaft in Hinsicht auf ihre Herkunft, Erfahrungen und Lebensweisen. Wir erkennen die Bereicherung, die diese Vielfalt birgt, und fördern Inklusion sowie eine Arbeitsumgebung, in der diese Unterschiede sich weiter entwickeln können, zur Stärkung des Lebens unserer Mitarbeiter, Patienten und Kunden.