Fixed-term of 3 years | Part-time with 65% | Salary according to TV-L E13
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise – ideally with you on board!
THE GROUP:
The Emmy Noether-funded research group of Dr. Dr. med. Alexander Busch investigates the regulation of the hypothalamic-pituitary-gonadal (HPG) axis—a key system in human reproductive development and fertility. The group combines clinical cohorts, population-scale genetics, and molecular biology to understand how early life periods, such as minipuberty and puberty, shape reproductive capacity.
The position is embedded in the IMF-funded project “ANDROGEN”, which aims to functionally validate newly identified genetic variants that regulate quantitative spermatogenesis. This integrative project combines GWAS, bulk and single-cell transcriptomics, protein validation, and regulatory reporter assays.
Learn more about the group here .
YOUR MISSION:
* Investigate how genetic variants affect male reproductive function
* Perform single-nucleus and bulk RNA sequencing of testicular tissue
* Validate gene expression at the protein level via IHC and Western blotting
* Analyze large-scale transcriptomic data (R, Python)
* Test allele-specific regulatory activity using luciferase reporter assays
* Integrate omics data to identify functional variants affecting spermatogenesis
REQUIREMENTS:
* A Master’s degree in Biology, Molecular Medicine, Biochemistry, Biotechnology, or a related discipline
* Solid wet-lab experience in molecular biology, ideally with tissue or protein work
* Motivation to develop bioinformatics and data analysis skills (training provided)
* Proficiency in English (spoken and written); German is a plus but not required
* Team spirit, communication skills, and scientific curiosity
* Prior experience with transcriptomics and/or reproductive biology
WE OFFER:
* A full 3-year PhD position within a dynamic Emmy Noether group
* A central role in a cutting-edge multi-omics project with direct translational relevance
* Individual mentoring, conference participation, and career development support
* A collaborative, international, and family-friendly work environment
For inquiries, please contact: Dr. Dr. med. Alexander S. Busch, alexandersiegfried.busch@ukmuenster.de
Apply now via our career portal until 27.08.2025 including:
* A motivation letter describing your interest in reproductive biology and genomics
* A brief summary of your laboratory and/or analytical experience
* Your CV
* Names and contact details of 1–2 referees willing to provide a letter of reference