AUFGABEN & PROFIL
BENEFITS
KONTAKT
UNIVERSITÄTSMEDIZIN
EINDRÜCKE
JETZT BEWERBEN
* PhD Student - Quantitative Spatial Biology Research Group
Anstellungsart: befristeter Vertrag
Arbeitsmodell: Voll- oder Teilzeit
Ausschreibungsnummer
* ...you're in the middle of it
We are seeking a highly motivated PhD Student to join our „Quantitative Spatial Cancer Biology" research group at the Dr. Senckenberg Institute of Pathology and the Mildred Scheel Career Center (MSNZ) Frankfurt, an excellence program supporting careers in translational cancer research (funded by the German Cancer Aid). The lab, headed by Dr. Konstantinos Kokkaliaris, specializes in hematopoietic stem-cell biology and bone marrow tissue organization in health, aging and cancer. We use innovative single-cell protein profiling technologies including cutting-edge multiplex 3D tissue imaging, multicolor flow cytometry and mass cytometry. The focus of the lab is to better understand tissue organization in homeostasis, aging and disease as well as further develop multiplex tissue imaging modalities. We are looking for a candidate interested in deciphering the cross-talk mechanisms through which tumor cells interact and prime their local tissue microenvironment to favor disease progression at the expense of healthy tissue function, using singe-cell technologies and in vivo models.
Further information on the lab can be found here: .
Project description
The project aims to define the key cellular, molecular and structural alterations in the bone marrow in malignant conditions. We will focus on targetable interactions between cancer cells and their spatial tumor microenvironment(s) to bypass cancer progression and metastasis, while enhancing healthy tissue function. Our goal is to leverage those findings towards the development of novel therapeutic intervention strategies for longer disease-free survival.
Relevant Publications:
Hofmann J. and Kokkaliaris KD. Bone marrow niches for hematopoietic stem cells: life span dynamics and adaptation to acute stress. Blood. 2020;
Kokkaliaris KD
and Scadden DT. Cell interactions in the bone marrow microenvironment affecting myeloid malignancies. Blood Advances. 4(15):. ( Cover story )
Kokkaliaris KD *
, Kunz L, Cabezas-Wallscheid N, Christodoulou C, Renders S, Camargo F, Trumpp A, Scadden DT, Schroeder T*. Adult blood stem cell localization reflects the abundance of reported bone marrow niche cell types and their combinations. Blood. 2020;:. *co-corresponding authors ( Cover story )
Coutu D+, Kokkaliaris KD+, Kunz L+, Schroeder T. Multicolor quantitative confocal imaging cytometry. Nature Methods, 2018; 15: 39-46. +co-first authors
Coutu D+, Kokkaliaris KD+, Kunz L, Schroeder T. Three-dimensional map of nonhematopoietic bone and bone-marrow cells and molecules. Nature Biotechnology, 2017;:. +co-first authors (Cover story)
... your skills are what we're looking for
Master’s degree in life sciences, biology or equivalent
* Experience in basic laboratory techniques (i.e. molecular biology)
* Passion for discovery, collaborative spirit & good communication skills
* Previous experience in immunofluorescence staining, flow cytometry and imaging is a plus
* Basic experience in image analysis and/or bioinformatics is a plus
* FELASA accreditation or previous experience with animal models is a plus
* Proficiency in spoken and written English
* Due to legal regulations, valid proof of measles immunity / measles vaccination is required
... you'll be offered a lot
Scientific Environment
: Excellent scientific environment & dedicated mentoring, training on cutting-edge single-cell technologies
Training: Participation in training and qualification programs of the MSNZ and the Goethe university
Collaboration: Collaboration opportunities with national & international expert laboratories
Campus: Attractive university hospital campus offers modern cafeterias, and opportunities to rest in numerous green spaces. A walk on Main riverside offers relaxation during breaks
Collective agreement
* : The position (65% - E 13) is initially limited for 3 years with the possibility for extension
Mobility: Free public transport in all Hessen (Free State Ticket Hessen)Gesundheitsförderung
Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays
Health Promotion: Benefit from attractive health offers and regular online and face-to-face courses on nutrition, relaxation, sports and exercise
Insights: Instagram, YouTube, LinkedIn
FAQ´s for new employees
* It's time to join our team!
Contact: Dr. Konstantinos Kokkaliaris
Email: Twitter/X : @kd_kokkaliaris
Application Deadline: 17.11.2025
We welcome applications from candidates of all genders. Women are currently underrepresented in these positions at Universitätsmedizin Frankfurt. Therefore, applications from women are especially encouraged. Applicants with severe disabilities will be given preferential consideration in cases of equal personal and professional qualifications.
JETZT BEWERBEN
* … sind Sie mittendrin in der Medizin von morgen
Genau hier sind Sie mittendrin in der Medizin von morgen. Die Universitätsmedizin Frankfurt gehört zu den führenden Universitätskliniken in Deutschland. Bei uns ziehen über 8.500 Menschen aus über 100 Nationen an einem Strang. Aus Wissen wird Gesundheit - das ist dabei unser täglicher Antrieb. Denn wir verbinden Krankenversorgung mit Forschung und Lehre, begrüßen den Fortschritt und entwickeln uns selbst immer weiter. So leisten wir einen wichtigen Beitrag für die Gesundheit und die Lebensqualität von über 500.000 Patientinnen und Patienten jährlich: kompetent, gewissenhaft und mit Leidenschaft.
› ‹
* UNIVERSITÄTSMEDIZIN FRANKFURT | RECRUITING TEAM | THEODOR-STERN-KAI 7 |FRANKFURT AM MAIN
* Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button „Jetzt bewerben“ ein.
* Rückfragen können Sie gerne an richten.
* Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram (@unimedizin_ffm); XING, LinkedIn, Youtube .
JETZT BEWERBEN