The Sigrist Lab at the Institute of Biology, Freie Universität Berlin, invites applications for a Postdoctoral Researcher position within the ERC-funded project SynProtect. The project investigates how neurons maintain both flexibility and stability - how synapses adapt to experience and stress while preserving precise communication under conditions such as sleep deprivation or aging.
Our research focuses on molecular and biophysical mechanisms of presynaptic plasticity, in particular how the Rab-GTPase regulator Blobby and aPKC/Par-1 kinase signaling jointly control the organization and remodeling of the active zone (AZ) via phase separation and endomembrane interactions. By combining molecular, imaging, and behavioral approaches, we aim to link synaptic remodeling with sleep and resilience at the organismal level.
We offer a stimulating and international research environment, access to state-of-the-art microscopy, proteomics, and behavioral platforms, and integration into the vibrant Berlin neuroscience community.
Job description:
- Conduct molecular and biochemical analyses of synaptic proteins (purification, phosphorylation dynamics, condensate assays)
- Apply Drosophila genetics and advanced microscopy for studying presynaptic plasticity
- Contribute to behavioral assays (sleep, stress resilience)
- Collaborate within the ERC project and with partner laboratories
Requirements:
- completed academic university studies (Masters/Diploma) and
- PhD in Molecular Neuroscience, Biochemistry, or a related discipline
(Professional) Experience:
- Proven expertise in Drosophila neurogenetics (mandatory)
- Strong background in protein biochemistry and synaptic biology
Desirable:
- Experience in advanced imaging, EM, or behavioral analysis is advantageous
- High motivation, independence, and interest in conceptual neurobiology