At the DKTK partner site Frankfurt/Mainz (work location: Department of Hematology and Medical Oncology at the University Medical Center Mainz), an MTA/TA is sought for the DKTK research project ''ASTRON". The main task is to carry out experiments (in vitro and 3D bioprints) based on next-generation cellular interventions that can work synergistically with mRNA intervention. The candidate will separately develop interventions and test these in conjunction with mRNA patterns.
Your Tasks
The main activities include:
* Cell culture (immune cells, tumor cell lines, but also tissue explants from fresh, healthy or cancer patients, microscopy analysis)
* CAR/TCR-engineering T cells
* mRNA interventions within the tumor microenvironment
* DNA and mRNA preparation, PCR, Western Blotting
* Functional testing (tumor cell targeting and killing by CAR/TCR-equipped T cells, analysis of T cell metabolic fitness etc.)
* In vivo oncology/PDX models (mouse studies)
* Maintenance of in vitro cell lines
* Administration and documentation (assist with analysis of data, the preparation of research publications and reports, conduct literatuer searches, and also order lab supplies)
* Assist in designing and planning research project-related experiments with the group leader
* Performing laboratory-based research with the requirements of good laboratory practice using a range of techniques, including in immunology, cellular biology, biochemistry and lately in vivo mouse studies
Your Profile
* BTA, MTA or equivalent
* Prior experience with cell culture and in molecular biology and biochemistry methods
* Team spirit
* Good German and English communication skills
We Offer
Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
30 days of vacation per year
Flexible working hours
Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
Possibility of part-time work
Family-friendly working environment
Sustainable travel to work: subsidized Germany job ticket
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