We are inviting applications for a Postdoc (m/f/d) at the Institute of Molecular Medicine The position is funded by Deutsche Krebshilfe in the research group of Prof. Dr. Michael Böttcher ( www.boettcher-lab.net ) at the Faculty of Medicine. The Project Join our dynamic and interdisciplinary team as we develop and apply innovative, patient-specific preclinical models to advance precision oncology in colorectal cancer. Our aim is to better understand how tumors interact with their surrounding microenvironment in order to identify novel therapeutic strategies for patients with advanced disease. To achieve this, we employ a cutting-edge toolbox that includes 3D tumor organoid cultures, single-cell transcriptomics, and CRISPR-based genome engineering. These technologies allow us to investigate tumor heterogeneity and cellular interactions with unprecedented resolution and to pinpoint actionable vulnerabilities that can be targeted in future therapies. Cultivation of colorectal cancer organoids and cells of the tumor microenvironment Execution of single-cell RNA sequencing (scRNA-seq) experiments Genetic manipulation of cells using CRISPR Independent project management Participation in national and international research collaborations Opportunity for scientific qualification Completed PhD in the life sciences First-author publications in peer-reviewed journals Proficiency in human cell culture techniques, ideally including experience with tumor organoid culture Experience with lentiviral transduction, molecular cloning, CRISPR genome editing, and scRNA-seq Programming experience in R or Python is an advantage Excellent command of English, both written and spoken Strong analytical and problem-solving skills Ability to work effectively in a team Access to excellent facilities for flow cytometry, imaging, CRISPR screening, single-cell RNA sequencing, and proteomics A highly collaborative project with opportunities for publications and participation in international conferences Salary according to TV-L E13 (100 %) Funding for 3 years (with potential for extension)