We are looking for a highly motivated PhD student to join the team of Dr. Sebastian Scheich at the Department of Hematology and Oncology at the Goethe University Hospital Frankfurt. The position is limited to a period of 3 years. The Department offers the full spectrum of blood and cancer diagnostics and therapy. The Emmy-Noether research group of Dr. Sebastian Scheich is part of the Frankfurt Cancer Institute (FCI, https://fci.health) and focuses on aggressive lymphoma biology and signaling. The lab is furthermore funded by grants from philantropy and several governmental organizations (BMFTR, DFG) and is embedded in a vibrant research environment within the FCI and maintains lively international collaborations. We apply cutting-edge technologies including genome-wide CRISPR/Cas9 screens, quantitative functional proteomics and super resolution microscopy (dSTORM, single molecule tracking, SIM) to dissect oncogenic signaling pathways, study therapy resistance mechanisms and to find novel therapeutic vulnerabilities. The current research projects are based on a recent publication identifiying N-linked glycosylation as a therapeutic target for the treatment of aggressive lymphomas (Scheich et al., Cancer Disc May 4:CD-22-1401; Phelan and Scheich et al. Cancer Cell. 2024 Feb 12;42(2):238-252.e9). Your project will be a follow-up based on preliminary data to mechanistically dissect oncogenic signalling pathways in lymphoma models Conduction of genome scale CRISPR/Cas9 screens and functional proteomic experiments including posttranslational modification profiling Utilization of cutting-edge imaging modalities including dSTORM, single molecule tracking, structured illumination micrscopy (SIM) and proximity ligation assays Use of preclinical in vivo mouse models to study lymphoma biology Independent planning, execution and analysis of experiments in the field of lymphoma research Application of standard molecular biology and biochemistry methods (tissue culture, flow cytometry, western blotting) Master degree or equivalent in molecular medicine, biology, biochemistry or a related field Solid hands-on research experience in basic cell biology, biochemistry and molecular biology methods Confidence and willingness to work with rodent models Fascination and motivation for biomedical research in the field of cancer biology Enthusiasm to learn and implement novel technologies High motivation for experimental lab work, analysis of “omics” data and data presentation Ability to work in a team, sense of responsibility and proactivity Basic knowledge in MS Office (Word, Excel) Fluent in English Due to legal regulations, valid proof of measles immunity / measles vaccination is required. TV-G-U E13 (65%) In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes Interaction with the National Cancer Institute (Bethesda, USA) Funding secured for at least 3 years and extension possible if needed Internal and external training for your professional development Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays Uniklinik-Campus, Mensa, Cafés Free public transport in all Hessen (Free State Ticket Hessen) Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise Insights: Instagram, YouTube, LinkedIn FAQ´s for new employees