Job Title: Postdoctoral Researcher in Bioinformatics
Our research team is dedicated to uncovering the mysteries of stromal-epithelial crosstalk in colorectal cancer initiation, progression and therapy resistance. Leveraging cutting-edge single-cell RNA sequencing and spatial transcriptomics techniques, we aim to decipher the mechanisms driving CAF-driven CRC evolution.
The primary focus of this project will be to elucidate how fibroblasts from healthy colon tissue transition into distinct CAF subtypes and how these subtypes regulate epithelial plasticity and immune responses. This work will integrate spatial transcriptomics, advanced co-culture organoid assays, and in vivo models to understand how stromal interactions change under current novel treatments and could be harnessed as future therapies.
You will apply innovative bioinformatics approaches to human-relevant models and unique patient-derived tissue cohorts from colorectal cancer. Your goal will be to dissect the tumor ecosystem through rigorous analysis and implementation of new tools, ensuring proper scientific documentation along the way.
* Bioinformatics analysis and tool implementation
* Data collection, interpretation, and analysis
* Scientific documentation