The newly established Ghosh lab utilizes state-of-the-art fluorescence imaging modalities, namely single-molecule localization microscopy (SMLM), lattice light-sheet microscopy (LLSM), and expansion microscopy (ExM), to study the (a) molecular binding mechanisms and dynamic interactions of therapeutic monoclonal antibodies (mAbs) and target antigens on tumor cell membranes and (b) cell-cell interactions between chimeric antigen receptor (CAR) engineered T cells and tumor cells. The scientific aims and scope of the research group are cross-disciplinary, with core expertise in biophysics and cell biology and a clinical focus on hematological malignancies, in particular multiple myeloma (MM).
Key references:Therapeutic monoclonal antibodies (mAbs) and CAR T cell-based immunotherapies are revolutionizing the treatment landscape in MM. Examples include, but are not limited to, monoclonal antibodies targeting CD38, bispecific antibodies targeting GPRC5D × CD3, and BCMA × CD3. Despite being in clinical use, the molecular binding mechanisms of antibodies and the target antigens remain elusive. The prospective doctoral candidate will be trained and is expected to design and implement advanced fluorescence imaging experimental workflows (SMLM and/or lightsheet and/or expansion microscopy) with the aim of discerning the intricate spatial organization of BCMA and GPRC5D antigens on MM cell membranes when treated with traditional and bispecific mAbs, with the final aim of understanding mechanisms of antigen escape in MM treatment.
Experience with the following is a plus:
Please apply with your CV, motivational letter, and certificates, as well as contact information for 2 referees.
Shortlisted candidates will be invited for an interview in late July/early August.