About the Company Our client is a leading Contract Development and Manufacturing Organization (CDMO) specialising in drug substance (API) development and manufacturing. With a reputation for scientific excellence, operational reliability, and long-term client partnerships, they deliver high-quality, scalable solutions that advance therapies from clinical to commercial stages. The Opportunity We are seeking an exceptional Site Director / General Manager to lead a key manufacturing site of approximately 200 employees, encompassing multiple production units and technical functions. This is a pivotal leadership role responsible for setting the site’s strategic direction, ensuring operational excellence, and driving business growth in alignment with corporate objectives. Key Responsibilities Strategic Leadership: Define and execute the site strategy in alignment with global business goals, ensuring sustainable growth, operational excellence, and client satisfaction. Operational Management: Oversee all aspects of manufacturing, supply chain, technical operations, and quality, ensuring safe, efficient, and compliant delivery of products. EHS & Compliance: Champion a strong safety culture and ensure full adherence to EHS, GMP, and regulatory standards. P&L Ownership: Manage the full site P&L, driving cost efficiency, productivity improvements, and margin enhancement. People Leadership: Inspire, develop, and empower a diverse workforce, fostering a culture of engagement, collaboration, and accountability across functions. Continuous Improvement: Lead initiatives in Lean, digital transformation, and process optimisation to enhance reliability, flexibility, and customer satisfaction. Business Development: Partner with commercial teams to support client relationships, new project onboarding, and business expansion opportunities. Stakeholder Engagement: Serve as the primary representative of the site to internal leadership, customers, and regulatory authorities. Candidate Profile Proven experience in a senior operational leadership role within a pharmaceutical CDMO or API manufacturing environment. Strong technical understanding of drug substance processes, GMP operations, and regulatory expectations. Demonstrated ability to lead large teams (>150 people) across multiple disciplines. Track record of strategic execution, financial acumen, and continuous improvement. Strong leadership, communication, and stakeholder management skills. Degree in Chemical Engineering, Chemistry, Pharmaceutical Sciences, or related field; MBA or advanced degree desirable. Why Join Lead a major manufacturing site at the forefront of API innovation. Shape the strategic direction of a growing, global CDMO. Be part of an organization that values science, people, and long-term partnerships.